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EBOV GP binding site residues
The EBOV GP gene encodes two glycoproteins: the surface glycoprotein GP and the small nonstructural glycoprotein sGP. Both are secreted from infected cells and expressed through co-transcriptional RNA editing. The two glycoproteins are structurally different, which may explain why surface GP is not recognized by virus-neutralizing monoclonal antibodies. The GP proteins are assembled in homotrimers, and they are responsible for the spikes on the surface of virions.
The EBOV GP protein is composed of three major antigenic sites: the base region, the head domain, and the glycan cap. By mutagenesis of EBOV GP libraries, the binding site residues of these proteins were identified and characterized. The results revealed that these residues play a central role in protective immunity against EVD.
These residues are essential for the antiviral activity of monoclonal antibodies. In addition, they are critical for the epitope on which mAbs bind. The reactivity of EBOV GP clones was evaluated using reference EBOV-GP-reactive mAbs. This helped identify the critical clones that bind to the EBOV GP. Moreover, it enabled the identification of critical clones that are important for the mAb epitope
Indus Valley Civilization
Mohenjo-Daro is one of the major sites of the Indus Valley Civilization. It is believed to have been a large city in the early Indus civilization. The city was abandoned around 1900 BCE. The civilization declined from about 1900 to 1300 BCE, possibly due to climate change and over-intensive farming. The decline is also likely related to the arrival of Aryan invaders in the early 1300 BCE, who may have assimilated the advanced Indus Valley culture.
Other major sites of the civilization include Suktagendor, which is situated 55 km from the Arabian Sea on the border of Iran. It was an important coastal city and the western boundary of the Indus Valley Civilization. It was an important port, but a rise in the coastal area caused it to become cut off from the sea. It had trade relations with Babylonia. Another 메이저사이트is Kot Diji, which is located on the left bank of the river Sindh. The site is notable for the terracotta figurines and unicorn seals.
The Indus Valley Civilization was an advanced civilization that lasted for five thousand years. It spread across the regions of present-day India and Pakistan. Its civilization developed an advanced writing system and was home to advanced culture. Hinduism also has its roots in the Indus Valley Civilization.
Ming Tombs
The Ming Tombs is located at the foot of a small hill. The tomb complex contains thirteen mausoleums. The tombs are similar in size and design but are distinguished by their varying structural complexity. The Ming Tombs are arranged in a fan shape around the Changling Tomb, with the Siling Tomb separate in the southwest corner. The tombs are surrounded by statues of officials and guardian animals.
The Ding Mausoleum, located southwest of the Chang Mausoleum, was built during the Ming dynasty between 1584 and 1590. It contains the tomb of the thirteenth emperor, Zhu Yijun (1563-1620). The tomb contains 3,000 unrevealed articles, including gold filaments.
The tomb is a major site and should be included in an organized tour. While many cheap tours skip this stop, it’s important to find one that includes both sites. You may need to walk for quite a while, so it’s best to plan accordingly.
Temple of Heaven
The Temple of Heaven is a major site in China’s ancient history. Its design represents Heaven and Earth. Its walls have square and semi-circular shapes and the northern part is higher than the southern part, a symbol of the heavens. The northern and southern walls are connected by a stone bridge, which is 360 meters long and 30 meters wide.
The temple has a circular altar at its center. The emperors performed sacrificial ceremonies here each year. It is in the shape of a circle and rises 38 meters above the ground. Its triple-gabled structure is constructed on three layers of marble stone. Its ceiling is carved with nine dragons and is covered with blue tiles.
This complex covers two hundred and seventy-three hectares and contains the Temple of Heaven. The first part of the Temple was finished in 1420 but later was rebuilt after it was destroyed by fire. The second phase was completed in 1890 after it was damaged by fire. Its design is unique. The temple is a fusion of ancient and modern styles and has a beautiful, detailed exterior and interior.
